Brain–machine interfaces1,2 use neuronal activity recorded fromthe brain to establish direct communication with external actuators, such as prosthetic arms. It is hoped that brain–machine interfaces can be used to restore the normal sensorimotor functions of the limbs, but so far they have lacked tactile sensation. Here we report the operation of a brain–machine–brain interface (BMBI) that both controls the exploratory reaching movements of an actuator and allows signalling of artificial tactile feedback through intracortical microstimulation (ICMS) of the primary somatosensory cortex. Monkeys performed an active exploration task in which an actuator (a computer cursor or a virtual-reality arm) was moved using a BMBI that derived motor commands from neuronal ensemble activity recorded in the primary motor cortex. ICMS feedback occurred whenever the actuator touched virtual objects. Temporal patterns of ICMS encoded the artificial tactile properties of each object. Neuronal recordings and ICMS epochs were temporally multiplexed to avoid interference. Two monkeys operated this BMBI to search for and distinguish one of three visually identical objects, using the virtual-reality arm to identify the unique artificial texture associated with each. These results suggest that clinical motor neuroprostheses might benefit from the addition of ICMS feedback to generate artificial somatic perceptions associated with mechanical, robotic or even virtual prostheses.

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The dynamic simulation of incomplete spinal cord in-jured individuals equipped with active orthoses is a challenging problem due to the redundancy of the simu-ltaneous human-orthosis actuation. The objective of this work is two-fold. Firstly, a physiological static optimization approach to solve the muscle-orthosis actuation sharing problem is presented. For this pur-pose, a biomechanical model based on multibody dynamics techniques is used. The muscles are modeled as Hill-type actuators and the atrophy of denervated muscles is considered by adding stiff and dissipative elements. Secondly, the mechanical design of a new active stance-control knee-ankle-foot orthosis (A- CKAFO) is addressed. The proposed device consists of a passive joint that constrains ankle plantar fle-xion, along with a powered knee unit that prevents flexion during stance and controls flexion-extension du-ring swing. The knee actuation is selected based on the results obtained through the optimization ap-proach.

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Background: Interpreting gait data is challenging due to intersubject variability observed in the gait pattern of both normal and pathological populations. The objective of this study was to investigate the impact of using principal component analysis for grouping knee osteo-arthritis (OA) patients’ gait data in more homogeneous groups when studying the effect of a physiotherapy treatment. Methods: Three-dimensional (3D) knee kinematic and kinetic data were recorded during the gait of 29 participants diagnosed with knee OA before and after they received 12 weeks of physiotherapy treat-ment. Principal component analysis was applied to extract groups of knee flexion/extension, adduction/abduction and internal/external rotation angle and moment data. The treatment’s effect on parameters of interest was assessed using paired t-tests performed before and after grouping the knee kinematic data. Findings: Increased quadriceps and hamstring strength was observed following treatment (Pb0.05). Except for the knee flexion/extension angle, two different groups (G1 and G2) were extracted from the angle and moment data. When pre- and post-treatment analyses were performed considering the groups, participants exhibiting a G2 knee moment pattern demonstrated a greater first peak flexion moment, lower adduction moment impulse and smaller rotation angle range post-treatment (Pb0.05). When pre- and post-treatment comparisons were performed without grouping, the data showed no treatment effect. Interpretation: The results of the present study suggest that the effect of physiotherapy on gait mechanics of knee osteoarthritis patients may be masked or underestimated if kinematic data are not separated into more homogeneous groups when performing pre- and post-treatment comparisons.

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Series elastic actuators (SEA) have been widely applied to bipedal robots and orthotic/ prosthetic devices since its first introduction to robotics world. Comparing to conventional ‘stiff’ actuation, SEA has the advantages in terms of low output impedance, high force fidelity, and energy storing capability. For portable rehabilitation devices such as exoskeletons, the demand on highly efficient and lightweight actuation imposes great challenge. The purpose of this paper is to discuss the possible way of choosing components and optimizing the design for a series elastic actuator so that we can achieve a better design in terms of efficiency maximization and weight/size reduction.

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Walking and sit to stand are activities carried out by all the people many times during the day, but physical disabilities due to age and diseases create needs of assistive devices to help elderly people during their daily life. This study aims to study the different types and mechanisms of the assistive devices. We will analyze the limitations and the challenges faced by the researchers in this field. We will introduce the Assistive Device developed at the Egypt-Japan University of Science and Technology, named E-JUST Assistive Device (EJAD). EJAD will be a low cost intelligent assistive device to help elders in walking and sit-to-stand activities.

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