A therapy and mobility assistance system used by a patient that includes a leg device worn on the leg of the patient that provides assistance and/or resistance to enhance the mobility of the leg of the patient, a therapy shuttle that facilitates therapeutic extension and flexion of at least one of the joints of the leg of the patient, and an appendage fastener that selectively couples the therapy shuttle and the leg device. The therapy and mobility assistance system may additionally include a guide track that constrains motion of the therapy shuttle along a path.

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