The visual grasp reflex provides automatic orienting of gaze (the visu-al axis in space) to novel visual stimuli. Previous studies have demonstrated activation of neck muscles of awake monkeys appearing at a short fixed latency (55 to 95 ms) after visual target presentation, regard-less of whether or when saccades are made. The purpose of these early visually-driven muscle activations may be to prime head rotation required as a part of the coordinated eye-head movement to the target. Simi-lar orienting responses might be found for visually guided reaching. Here, we explore early visually-dri-ven muscle activations of the human upper limb immediately preceding planar reaching movements. Subjects performed reaches towards small visual peripheral targets while upper limb kinematics were recorded and intramuscular electromyography was collected from four shoulder and elbow muscles. Subjects maintained their right hand at a central fixation marker that was extinguished for a gap period (200 ms) prior to appearance of a peripheral target. Subjects were instructed to reach to the target as quickly as possible. Some subjects exhibited a short burst of muscle activity (about 20 ms duration) time-locked to visual target onset. This burst occurred around 85 ms to 105 ms after target onset and preceded the onset of muscle activity associated with volitional arm motion by about 100 ms. Notably, this burst was dependent on target location: visually-driven muscle activity occurred in right shoulder extensor muscles for rightward targets and was absent for leftward targets. In order to better dissociate the visual burst from volitional motor activity, we employed a delay paradigm. No time-locked muscle activity was present in the delay task either after the target appeared or after the fixation marker was extinguished. This suggests that the visual burst is dependent on the imminence of voluntary movement and the laterality of the tar-get. We conclude that the appearance of a visual target can result in short-latency activity on the arm musculature that is appropriate for orienting the arm to the target.

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The gravity balancing exoskeleton, designed at University of Delaware, Newark, consists of rigid links, joints and springs, which are adjustable to the geometry and inertia of the leg of a human subject wearing it. This passive exoskeleton does not use any motors but is designed to unload the human leg joints from the gravity load over its range-of-motion. The underlying principle of gravity balancing is to make the potential energy of the combined leg-machine system invariant with configuration of the leg. Additionally, parameters of the exoskeleton can be changed to achieve a prescribed level of gravity assistance, from 0% to 100%. The goal of the results reported in this paper is to provide preliminary quantitative assessment of the changes in kinematics and kinetics of the walking gait when a human subject wears such an exoskeleton. The data on kinematics and kinetics were collected on four healthy and three stroke patients who wore this exoskeleton. These data were computed from the joint encoders and interface torque sensors mounted on the exoskeleton. This exoskeleton was also recently used for a six-week training of a chronic stroke patient, where the gravity assistance was progressively reduced from 100% to 0%. The results show a significant improvement in gait of the stroke patient in terms of range-of-motion of the hip and knee, weight bearing on the hemiparetic leg, and speed of walking. Currently, training studies are underway to assess the long-term effects of such a device on gait rehabilitation of hemiparetic stroke patients.

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This paper introduces a newly developed gait rehabilitation device. The device, called LOPES, combines a freely translatable and 2-D-actuated pelvis segment with a leg exoskeleton containing three actuated rotational joints: two at the hip and one at the knee. The joints are impedance controlled to allow bidirectional mechanical interaction between the robot and the training subject. Evaluation measurements show that the device allows both a «patient-in-charge» and «robot-in-charge» mode, in which the robot is controlled either to follow or to guide a patient, respectively. Electromyography (EMG) measurements (one subject) on eight important leg muscles, show that free walking in the device strongly resembles free treadmill walking; an indication that the device can offer task-specific gait training. The possibilities and limitations to using the device as gait measurement tool are also shown at the moment position measurements are not accurate enough for inverse-dynamical gait analysis.

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Exoskeletons are mechatronic systems worn by a person in such a way that the physical interface permits a direct transfer of mechanical power and exchange of information. Upper limb robotic exoskeletons may be helpful for people with disabilities and/or limb weakness or injury. Tremor is the most common movement disorder in neurological practice. In addition to medication, rehabilitation programs, and deep brain stimulation, biomechanical loading has appeared as a potential tremor suppression alternative. This paper introduces the robotic exoskeleton called WOTAS (wearable orthosis for tremor assessment and suppression) that provides a means of testing and validating nongrounded control strategies for orthotic tremor suppression. This paper describes in detail the general concept for WOTAS, outlining the special features of the design and selection of system components. Two control strategies developed for tremor suppression with exoskeletons are described. These two strategies are based on biomechanical loading and notch Altering the tremor through the application of internal forces. Results from experiments using these two strategies on patients with tremor are summarized. Finally, results from clinical trials are presented, which indicate the feasibility of ambulatory mechanical suppression of tremor.

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A broad objective of many lower extremity exoskeletons is to allow the wearer to expend less of their own energy for locomotion. Existing exoskeleton control algorithms are based on positive feedback. Forces are generated to augment movement initiated by the wearer. Positive feedback, however, can have destabilizing effects in dynamic systems. In fact, stability in these lower extremity exoskeletons is achieved by relying on the wearer’s neuromuscular system. Relying on the wearer to maintain stability may increase metabolic demand, which is counter productive to increasing efficiency. Thus, the goal of this study was to measure how a simple form of positive feedback that augments ankle push-off power affects both metabolic efficiency and dynamic walking stability. We developed a pair of powered ankle-foot orthoses (PAFOs) similar in design to Ferris, et al. (J. Appl. Biomech. 21, 189-197, 2005). Nine young healthy adults (23.3!1.6 years) walked on a treadmill in the PAFOs under two conditions. Metabolic energy expenditure was calculated using indirect calorimetry. Walking stability was quantified using techniques for studying stability of dynamic system trajectories. The maximum Lyapunov exponent for assessing local dynamic stability, and the maximum Floquet multiplier magnitude for assessing orbital stability were calculated from foot and shank kinematics for each condition. Greater Lyapunov exponents and Floquet multipliers indicate decreased stability. Walking with mechanically generated push-off power increased metabolic efficiency (2.58!0.39 to 2.97!0.38, p<0.01), did not affect local dynamic stability (0.14!0.02 to 0.14!0.02, p=0.77), but decreased orbital dynamic stability (0.43!0.03 to 0.48!0.06, p=0.05). This study provides evidence that positive feedback can negatively affect stability. Further investigations into understanding stability of movement will be necessary for the design of controllers for powered lower extremity exoskeletons.

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